How Does Alzheimer’s Affect the Brain? Part 3: Causes | Getting to Know Alzheimer’s: 12 Things You Must Know | Alzheimer’s Articles, Information and Resources

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Causes
Scientists believe that for most people, Alzheimer’s disease results from a combination of genetic, lifestyle and environmental factors that affect the brain over time.

Less than 5 percent of the time, Alzheimer’s is caused by specific genetic changes that guarantee a person will develop the disease.

While the causes of Alzheimer’s are not yet fully understood, its effect on the brain is clear. Alzheimer’s disease damages and kills brain cells. A brain affected by Alzheimer’s disease has many fewer cells and many fewer connections among surviving cells than does a healthy brain.

As more and more brain cells die, Alzheimer’s leads to significant brain shrinkage. When doctors examine Alzheimer’s brain tissue under the microscope, they see two types of abnormalities that are considered hallmarks of the disease:

• Plaques. These clumps of a protein called beta-amyloid may damage and destroy brain cells in several ways, including interfering with cell-to-cell communication. Although the ultimate cause of brain-cell death in Alzheimer’s isn’t known, abnormal processing of beta-amyloid is a prime suspect.

• Tangles. Brain cells depend on an internal support and transport system to carry nutrients and other essential materials throughout their long extensions. This system requires the normal structure and functioning of a protein called tau. In Alzheimer’s, threads of tau protein twist into abnormal tangles, leading to failure of the transport system. This failure is also strongly implicated in the decline and death of brain cells.

Reprinted with permission of Mayo Foundation for Medical Education and Research. All rights reserved.

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How do You Get Alzheimer’s? Part 4: Risk Factors

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Getting to Know Alzheimer’s: 12 Things You Must Know
What is Alzheimer’s? Part 1: Definition
How Can I Tell if it is Alzheimer’s? Part 2: Symptoms

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